Tumour on liver (Hepatoma)

Symptoms

Dropsy
Fluid retention in body cavity, cause scales to protrude

Abdomen swollen
Lower body of fish is bloated and swollen to a considerable degree.

Emaciation
Fish is fading away, looks as if it is starving to death.

Listless and lethargic
Fish moves very lazily in water, much less than normal, lacks interest.

Ulcers - irregular
Irregular shaped ulcers are evident on the skin.

Causes

Tumourous growth on liver. If it manifests itself on many fish Suspect food inputs . Especially watch for pesticide contamination, or Aflatoxins.

Prognosis

Almost invariably fatal. Veterinary operation if fish is especially valuable.

Treatment

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Prevention

DNA and RNA diagnostic references

Comparative genomic hybridisation of hepatocellular carcinoma: Correlation with fluorescence in situ hybridisation in paraffin-embedded tissue.

From Molecular Diagnosis Volume 6, Issue 1. March 2001, Pages 27-37

Uma N.M. Rao et al.

Note. This appears to be a medical reference.
Notwithstanding it also refers to FISH studies and the similarities of some of the chromosomes, so it could be a good start to finding specific sequences on Fish.